Page 7 - Renato Martins Araújo_M

CARACTERIZAÇÃO CLÍNICA E EPIDEMIOLÓGICA DA NEOPLASIA
PROSTÁTICA NOS ANOS DE 2012 A 2014 EM UM CENTRO DE

ONCOLOGIA DO LESTE DE MINAS GERAIS

Renato Martins Araújo

ABSTRACT

Prostate cancer (PCa) is the second most common cause of cancer in men. According to
INCA, in Brazil, in 2016, approximately 61,200 new cases of prostate cancer are
estimated. Objective: To identify the demographic and epidemiological characteristics, as
well as data on the tumor staging of patients with PCa treated at the Oncology Unit of
Hospital Marcio Cunha in the city of Ipatinga-MG in the years of 2012, 2013 and 2014.
Methodology: This is a retrospective and descriptive study where 668 patients' records,
with a diagnosis of pathological diagnosis, were analyzed in the years 2012, 2013 and
2014, according to the list provided by the institution, with a diagnosis of PCa registered
with ICD-10-C 61. The analyzed variables were: origin, year of diagnosis, age group, self-
reported race, risk factors such as smoking, alcoholism, family history of PCa, total PSA at
diagnosis, histological type of biopsy, Gleason score of biopsy, histological type of the
surgical specimen, Gleason score of the surgical specimen. Data were analyzed using
descriptive and inferential statistics, using SPSS software, version 19.0. Results: The
highest incidence of PCa cases came from the most populated cities of the analyzed
health micro-region and the most prevalent age group was between 61 and 80 years old,
with prevalence in brown and whites and with a family history of 17.2% of first-degree
relatives degree; With father in 37.3%, brother in 60.8% and son in 1.9%. Only 165
(25.9%) were smokers and 20.8% were alcoholics. PSA levels ranged from 4.1ng / e to
10ng / ml (49.5%) and the higher the age group the higher the PSA values. Brown
patients had higher total PSA. When we evaluated whether there was a relationship
between total PSA levels and risk factors such as smoking, alcohol consumption and
family history, there was only a statistically significant relationship with alcohol
consumption. There was concordance of the Gleason score between biopsy and surgical
specimen in 70%, subgrade in 18.7% and overdose in 11.3%. Comparing the age of
patients with Gleason score, the greater the patient's age, the greater the Gleason score
of the material obtained by the transrectal biopsy. Smokers and alcoholists presented the
highest Gleason score of the surgical specimen. Conclusion: The agreement between
the Gleason score of the biopsy and the Gleason score of the surgical specimen was
70%; Higher PSA levels; The longer the age group, the more undifferentiated was the
tumor (biopsy); Smokers and alcoholics presented more undifferentiated tumors in the
surgical specimen; This is the first epidemiological study of PCa developed in the Vale do
Aço region, the socio-demographic characterization and the associations found here can
contribute with programs to develop actions of control of PCa in this region.

Key words: Prostate cancer. Epidemiology. Risk factors. PSA (prostate specific antigen).
Gleason score.